招聘简介：

　　冷泉港的谢尔茨实验室正在为一个研究癌症染色体畸变的资助项目寻找博士后研究人员。

　　大规模基因剂量失衡在人类肿瘤中普遍存在。例如，超过一半的乳腺癌含有染色体臂1q的扩增，使得这种变化在乳腺癌基因组中比TP53、BRCA1和BRCA2突变组合更常见。尽管这些非整倍体的出现频率很高，但人们对它们的出现原因以及它们如何影响肿瘤的进展知之甚少。

　　英文原文：

　　The Sheltzer Lab at Cold Spring Harbor is seeking postdoctoral researchers for a funded project studying chromosomal aberrations in cancer.

　　Large-scale gene dosage imbalances are ubiquitous in human tumors. For instance, more than half of all breast cancers harbor an amplification of chromosome arm 1q, making this alteration more common in breast cancer genomes than mutations TP53, BRCA1, and BRCA2, combined. Despite the frequency of these aneuploidies, little is known about why they arise or how they affect tumor progression.

　　The Sheltzer laboratory is pioneering new CRISPR-based chromosome engineering methods to study the role that gene dosage imbalances play in tumorigenesis. By precisely manipulating cancer karyotypes, we can uncover the unique consequences of specific aneuploidies, absent any other genetic alterations. These approaches have revealed multiple unexpected ways that aneuploidy can affect cancer physiology. We are seeking postdocs who are interested in using these techniques to uncover how chromosomal aberrations and chromosomal instability can influence cancer initiation, drug resistance, and metastatic dissemination.

　　The Sheltzer Lab is a highly-collaborative environment that values rigorous research and that welcomes scientists from all backgrounds. We are located at Cold Spring Harbor Laboratory, an immersive research institute on the outskirts of New York City. Cold Spring Harbor is an NCI-designated Cancer Center, and every year over 10,000 scientists journey to Cold Spring Harbor to attend one of CSHL’s renowned Meetings and Courses.

　　More information on research conducted in the Sheltzer Lab can be found on our website at www.sheltzerlab.org.

　　CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status.

　　Interested candidates should send a cover letter and CV to sheltzer@cshl.edu. Please also apply for this this position via the CSHL website at: http://cshl.peopleadmin.com/postings/14705

　　Position Number: 02279-R