Both G protein coupled receptors (GPCRs) and Wnt proteins play important roles in a wide range of biological and pathophysiological processes. We are currently using various biochemical, molecular and cell biological, structural biological, genomic, proteomic, large scale RNAi screening, and transgenic and gene targeting approaches to: 1) characterize signaling pathways and networks initiated from GPCR ligands and investigate their roles in regulation of leukocyte functions (chemotaxis, infiltration, survival, reactive oxygen production, and degranulation) and in infection and inflammation-related diseases; 2) interrogating signaling mechanisms underlying fibroblast and tumor cell migration and their roles in tumor metastasis and fibrosis; and 3) elucidate Wnt signaling mechanisms and their functions in tumorigenesis and stem cell biology.

Please see our recent publications and webpage for detail: Nature Comm. 6,8205; Cell Report 14,734; Dve. Cell 27,215; JCB, 200, 419; Nature Cell Biology 4, 686; Dev. Cell 21, 1038, Immunity 33, 340, Science 321, 1350, JCI 118, 195, Science 315, 1278, Science 314, 136, Nat Genet. 37, 945, Nat. Cell Biol. 7, 399, Cell 114, 215, Mol. Cell 7, 801, Science 287, 1046.

Competitive Salary and excellent work environment are offered. Self-motivated individuals with an advanced degree in any area of biomedical sciences and specially those who are skilled in advanced imaging and mouse work are encouraged to apply.