一、课题组简介

张一小，现任中科院生物与化学交叉中心研究员，博士生导师。2015年博士毕业于清华大学生命科学学院。2016至2020年，在美国洛克菲勒大学进行博士后研究并担任助理研究员。入选国家海外优青项目、上海市海外高层次人才引进计划，上海科技青年35人引领计划、上海脑科学与类脑研究中心“求索杰出青年”课题组长，中科院上海分院青年英才培育计划等。在利用冷冻电镜研究生物大分子的三维结构方面有超过十年的研究经验，致力于用冷冻电镜技术研究富有挑战性的生物学机制问题。在Nature,Science,MolecularCell,NatureStructural&MolecularBiology,NatureCommunication,PNAS因工作需要，博士后及科研助理。

岗位1：博士后及科研助理

岗位职责（满足以下1-2项即可）：

1.独立开展相关课题研究。

2.开展离子通道电生理实验。

3.开展药物筛选相关实验

4.开展细胞生物学实验。

5.开展冷冻电镜相关实验。

6.开展抗体筛选制备相关实验。

7.完成课题组长交代的其他任务。

岗位要求：

1.具有本科以上的细胞生物学、神经生物学、结构生物学、生物化学等相关专业学历。

2.工作认真细致，有良好的实验记录习惯。

3.具有良好的英文文献查找及阅读能力。

4.能长期稳定工作者优先。

三．待遇及福利：

工资和福利按照本人能力、工作业绩、中科院生物与化学交叉研究中心和国家有关规定从优，具体待遇面议。邮件标题请注明“应聘职位+姓名“。

五．工作地点：

上海市浦东新区海科路100号13号楼

六．代表性研究论文：

1.Han, Y., Zhou, Z., Jin, R., Dai, F., Ge, Y., Ju, X., Ma, X., He, S., Yuan, L., Wang, Y., Yang, W., Yue, X., Chen, Z., Sun, Y., Corry, B.# , Cox, C. D.#, and Zhang, Y.# (2024). Mechanical activation opens a lipid-lined pore in OSCA ion channels. Nature, 1-9.

2.Zhou, Z., Ma, X., Lin, Y., Cheng, D., Bavi, N., Secker, G.A., Li, J.V., Janbandhu, V., Sutton, D.L., Scott, H.S., Zhang, Y. #, Cox, C.D.# (2023). MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science, 381, 799-804.

3.Yuan, L., Han, Y., Zhao, J., Zhang, Y.#, and Sun, Y#. (2023). Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex. Nature Communications, 14, 6071.

4.Xia, A., Wang, X., He, J., Wu, W., Jiang, W., Xue, S., Zhang, Q., Gao, Y., Han, Y., and Li, Y., Peng, X., Xie, M., Mayer, C. T., Liu, J., Hua, C., Sha, Y., Xu, W., Huang, J., Ying, T., Jiang, S., Xie, Y., Cai, Q., Lu, L. #, Silva, I. T. #, Yuan, Z. #, Zhang, Y. #, and Wang, Q#. (2023). Cross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history. BMC biology, 21, 205.

5.Zhang, Y., Daday, C., Gu, R., Cox, C.D., Martinac, B., Groot, B., Walz, T. (2021). Visualizing the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 509-514.

6.Dan, J.*, Zhang, Y.*, Lee, C.H., Valencia-Sanchez, M., Zhang, J., Wang, M., Holder, M., Svetlov, V., Tan, D., Nudler, E., Reinberg, D., Walz, T., Armache, K. (2021). Structures of monomeric and dimeric PRC:EZH1 reveal flexible modules involved in chromatin compaction. Nature Communications, 12(1): 714.

7.Sun, Y.*, Zhang, Y.*, Aik, W.S., Yang, X.-C., Marzluff, W.F., Walz, T., Dominski, Z., and Tong, L. (2020). Structure of an active human histone pre-mRNA 3’-end processing machinery. Science 367, 700-703.

8.Zhang, Y.*, Sun, Y.*, Shi, Y., Walz, T., and Tong, L. (2020). Structural Insights into the Human Pre-mRNA 3’-End Processing Machinery. Molecular Cell 77: 800-809.

9.Su, M.*, Zhu, L.*, Zhang, Y.*, Paknejad, N.*, Dey, R., Huang, J., Lee, M.Y., Williams, D., Jordan, K.D., Eng, E.T., Ernst, O.P., Meyerson, J., Hite, R., Walz, T., Liu, W., Huang, X. (2020). Structural basis of the activation of heterotrimeric Gs-protein by isoproterenol-bound b1-adrenergic receptor. Molecular Cell 80:59-71.

10.Nešić, D.*, Zhang, Y.*, Spasic, A.*, Li, J.*, Provasi, D., Filizola, M., Walz, T., and Coller, B.S. (2020). Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex. Arteriosclerosis, Thrombosis, and Vascular Biology. 119.313671.

11.Yu, J.*, Zhang, B.*, Zhang, Y.*, Xu, C.Q., Zhuo, W., Ge, J., Li, J., Gao, N., Li, Y., and Yang, M. (2018). A binding-block ion selective mechanism revealed by a Na/K selective channel. Protein & Cell 9, 629-639.

12.Lees, J.A.*, Zhang, Y.*, Oh, M.S., Schauder, C.M., Yu, X., Baskin, J.M., Dobbs, K., Notarangelo, L.D., De Camilli, P., Walz, T., Renisch, K. (2017). Architecture of the human PI4KIIIalpha lipid kinase complex. Proc Natl Acad Sci. U.S.A 114, 13720-13725.

13.Sun, Y.*, Zhang, Y.*, Hamilton, K., Manley, J.L., Shi, Y., Walz, T., and Tong, L. (2017). Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc Natl Acad Sci. U.S.A 115, E1419-E1428.

14.Zhang, Y., Ma, C., Yuan, Y., Zhu, J., Li, N., Chen, C., Wu, S., Yu, L., Lei, J., and Gao, N. (2014). Structural basis for interaction of a cotranslational chaperone with the eukaryotic ribosome. Nature Structural & Molecular Biology 21, 1042-1046.

15.Wu, S., Tutuncuoglu, B., Yan, K., Brown, H., Zhang, Y., Tan, D., Gamalinda, M., Yuan, Y., Li, Z., Jakovljevic, J., et al. (2016). Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes. Nature 534, 133-137.

16.Li, N., Zhai, Y., Zhang, Y., Li, W., Yang, M., Lei, J., Tye, B.K., and Gao, N. (2015). Structure of the eukaryotic MCM complex at 3.8 A. Nature 524, 186-191.

* indicates co-first authors, # indicates co-corresponding authors

信息来源于网络，如有变更请以原发布者为准。

来源链接：

https://www.ircbc.cn/view.do?id=3278

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