希望之城国家医疗中心(City of Hope NationalMedical Center)是一所顶尖的美国非盈利研究和治疗中心，专注于癌症、糖尿病和其他危及生命的疾病。

该医疗中心是美国国立癌症研究院（National Cancer Institution）指定的53所癌症综合中心之一，也是美国国立综合癌症网络的创立会员和中央数据协调中心。被权威新闻杂志周刊《美国新闻与世界报道》(U.S News & World Report)列为全美最佳癌症医院第七名和“美国最佳癌症和泌尿科医院”之一。

Postdoctoral Fellow – Tumor Microenvironment and Leukemia – Carlesso Lab

City of Hope

Job Description

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

Dr. Nadia Carlesso’s research is focused on the mechanisms of leukemogenesis and identification of novel therapeutic approaches in poor prognosis T-ALL. Following recent laboratory discoveries, her group is exploring novel approaches to target the microenvironment/oncogene cooperation driving chemoresistance and relapse in T-ALL leukemia stem cells.

This project is nested on a larger program directed by Dr. Carlesso that focuses on the relationships between the tumor microenvironment, inflammation, and stem cell biology in hematopoietic diseases. Nadia Carlesso, M.D., Ph.D. | City of Hope

Dr. Carlesso is looking for Postdocs to advance the following areas of interest in her laboratory:

- Map the signal transduction oncogenic circuitry in drug-resistant and relapse T-ALL cells.

- Study the microenvironment and leukemic stem cells interactions.

This NIH-NCI funded position is created to expand our recent findings on oncogene cooperation in T-cell leukemogenesis (Rodriguez et al, Leukemia 2020), and on the development of a new in vitro platform to study leukemia/endothelium interactions (Kim et al., Nature Communications 2022).

Candidates with expertise in cell & molecular biology, biochemistry, and in vivo models who are interested in building a career in biomedical research will be most competitive for this position.

Key Responsibilities include:

· Designing and executing experiments.

· Keep detailed and accurate logs of experiments from conception to analysis.

· Prepare laboratory reagents, chemicals, instruments, and maintain equipment.

· Participate in the preparation of manuscripts for publication, grants and presentation.

· Supervise and provide mentorship to undergraduate students in the laboratory.

· Travel to meetings to represent the lab and to present new data.

Basic education, experience and skills required for consideration:

· A Ph.D. degree in life or biomedical sciences, or a related discipline is required. Ideal candidates will have just graduated or be within few months from graduation.

· Applicants must have a record of publications and at least one publication as first author.

· Self-driven, passionate, curious, and highly motivated to develop scientific and career skills.

· Collaborative and practice scientific integrity and honesty.

· Have expertise in cellular & molecular biology and biochemistry.

· Experience on signal transduction and nuclear hormone receptors or/and iPSCs or/and animal models is highly desirable.

The position will provide considerable opportunities to the postdoctoral fellow for further training and development of additional skills and expertise in a vibrant intellectual and multi-disciplinary scientific environment.

Additional Information:

· As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

· For more information on Dr. Nadia Carlesso’s research, please visit here.

Salary / Pay Rate Information:

Pay Rate: $31.00 - $34.23 / hour

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