Postdoctoral position in Bioinformatics

Max Planck Institute for Plant Breeding Research (MPIPZ)

Location:

Max Planck Institute for Plant Breeding Research, Cologne, Germany

Institute:

LMU Munich, Faculty of Biology, Munich, Germany

Group:

Prof. Korbinian Schneeberger

Starting date:

April 2022 (to be negotiated)

Apply until:

February 28th, 2022 (position remains open until filled)

Duration:

3 years

Postdoctoral position in Bioinformatics (m/f/d)

The Ludwig-Maximilians University Munich is one of the largest and most renowned universities in Germany.

Working environment:

The established group “Genome Plasticity and Computational Genetics” managed by Korbinian Schneeberger is focused on plant genomics, specifically on the development of novel computational and biotechnological methods for the analysis of genome sequences. The group is located at the Faculty of Biology at the LMU in Munich, with a part of the group working at the Max Planck Institute for Plant Breeding Research in Cologne, Germany. We are currently searching for a postdoc for our location at the MPI in Cologne.

Our group analyzes genomic changes on different levels. We compare the genomes between species, populations and artificial crosses. We do this using latest technologies (including third generation as well as single-cell genomic technology) to get insights into how and why genomes change over time. Current projects include genetic experiments and the establishment of computational methods for the analysis of multidimensional genome data to study the natural diversity of mutations and recombination.

We are a multi-disciplinary group including bioinformaticians, biologists and biotechnologists (schneebergerlab.org). Our approach to science is curiosity-driven, and is closely aligned to our interests in new genomic technologies. Scientific support comes from a wide range of facilities (genomics, microscopy, high performance compute clusters) and lab technicians. Salaries will be based on previous experience according to TV-L guidelines.

Project Description

We have recently developed a new method to assemble the individual haplotypes of tetraploid genomes based on the combination of long-read sequencing and the analysis of single pollen genomes (Sun et al, 2021, biorxiv). We applied this method for the reconstruction of the first fully haplotype-resolved assembly of a cultivated potato genome.

Following up on this work we now would like to make use of the individual haplotypes and develop genotyping methods for a simplified analysis of even more complex genomes. The method should then be applied to genotyping recombinant pollen genomes (which will allow us to analyze the inheritance on the individual haplotypes) as well as other potato cultivars. While applied in the context of plant genomics, such haplotype-type based genotyping would be applicable across many different species including even humans.

Qualifications

We are searching for highly motivated applicants with a PhD in bioinformatics or a similar field in computational biology. Applicants should be proficient in programming (Java, C/C++ etc.) or scripting and should have experiences in the analysis of next-generation sequencing data and in the use of a high-performance compute cluster. Good oral and writing skills in English are essential. We are particularly looking for open-minded, creative and critical minded candidates who like to work in an international team.

Disabled people with the appropriate qualifications will be considered preferably.

Have we raised your interest? Please submit your application to Finni Häußler (finni.haeussler@lmu.de). In case of questions, please directly email Korbinian Schneeberger (k.schneeberger@lmu.de).

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