3-Year Postdoc Position In Epigenetic Memory And Genome Stability

Description

Novo Nordisk Foundation Center for Protein Research (CPR)

Faculty of Health and Medical Sciences

University of Copenhagen

We are looking for a highly motivated postdoc with expertise in chromatin biology or genome stability to unravel molecular mechanisms that orchestrate the interplay between epigenome and genome maintenance.

The successful candidate will work at the Novo Nordisk Foundation Center for Protein Research (CPR) in the Chromatin replication and Epigenome maintenance research group headed by Prof. Anja Groth.

More information on the CPR can be found at: https: // www. cpr.ku.dk

Our research The focus of the Groth group is to elucidate how chromatin organization and function is propagated during mitotic cell division to maintain genome and epigenome stability. Our goal is to understand mechanisms that underpin chromatin replication and epigenetic cell memory and how they impact on cell fate decisions and genetic stability. We apply innovative proteomic and genomic approaches in combination with cutting-edge cell biology, high-content imaging, chromatin biochemistry and structural biology. Our group is diverse and multidisciplinary with many scientific collaborations nationally and internationally, and we put high value on idea sharing and use Creative Problem Solving tools to develop our research projects. We also have a translational focus connected to our spin-out company Ankrin Therapeutics.

The Groth Group is part of the Protein Memory Program at NNF CPR, a multidisciplinary and international research center with a highly collaborative research environment and cutting-edge core facilities, such as genomics, proteomics, protein imaging, protein production and characterization, big data management platforms.

Your job

The projects will address transmission of chromatin organization trough DNA replication and how this is linked to genome/epigenome stability. The interplays between histone dynamics and replication fork stability and chromatin restoration and genome fragility remain poorly understood. Our recent discovery that new histones control repair pathway choice is a new entry point to this question (Becker et al., 2021 Nature; Nakamura et al., 2019 Nat Cell Biol; Saredi et al., 2016 Nature). You will take an innovative multi-disciplinary approach to address these interplays, using our custom functional genomics tools (ChOR-seq, Repli-ATAC, SCAR-seq), replication fork proteomics (NCC / iPOND), high content imaging, super-resolution microscopy and genome-editing. You will be part of a highly collaborative group and we expect that you will join other ongoing projects and contribute actively to develop new exciting research strategies and supervision of students.

Profile We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

A PhD in Life science or related

Strong expertise in molecular biology, genetics, cell biology and/or biochemistry.

A background in chromatin biology, DNA replication and repair and/or stem cell biology is an advantage.

Expertise in super-resolution microscopy and/or next-generation sequencing (NGS) approaches and data analysis is a plus.

Highly collaborative mindset and curiosity driven nature

Proficient communication and organization skills

Excellent English skills written and spoken

Place of employment

The employment is at CPR (www. cpr.ku.dk), a Novo Nordisk Foundation center of excellence established in 2007 and embedded in the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied research on human proteins of medical relevance. The Center comprises modern laboratories, supercomputer resources and state-of-the- art facilities within protein science and genomics. CPR is an interdisciplinary international environment with English as the main language. We are located in central Copenhagen, a city with one of the highest qualities of life in the world and a vibrant and highly interactive research environment. The University of Copenhagen has a strong focus on balancing professional life with a family- friendly working environment https: // www. ism.ku.dk/faq .

Terms of employment The employment as postdoc is a full time and fixed-term position for 3 years. Starting date is 1 April 2022 or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 35,000 DKK/ approx. 4,600 Euro (October 2021-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Questions For further information please contact Prof. Anja Groth; e-mail anja.groth @cpr.ku.dk

Foreign applicants may find this link useful: www. ism.ku.dk (International Staff Mobility).

Application procedure Your online application must be submitted in English by clicking ‘Apply now' below. Furthermore, your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. CV incl. education, work/research experience, language skills, other skills relevant for the position, and names and contact details for 3 references.

3. Copies of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.

Application deadline: 30 January 2022, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https: // employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 9 and 10.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

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