奥地利格拉茨理工大学基因组学博士后研究职位

A position for a postdoctoral researcher is available at the Institute for Biomedical Informatics at Graz University of Technology (Austria). We develop and apply regulatory genomics and systems biology approaches to analyze large genomic datasets. Our long-term goal is to gain novel insights into the mechanisms and evolution of differential gene expression.

Eligibility criteria:

- Completed doctoral studies or equivalent in molecular biology, genetics, biochemistry, biotechnology, or a similar field.

- Practical laboratory experience sequencing with Oxford Nanopore Technologies.

- Profound knowledge and practical laboratory experience in the field of molecular genetics (DNA extraction and amplification, library preparation, cloning, qRT-PCR, etc.).

In addition, the ideal candidate should:

- Be highly motivated to independently familiarize herself/himself with a topic and develop solutions.

- Be interested in multidisciplinary work.

- Have strong logical and analytical skills.

- Have strong organizational skills.

- Be creative, independent, and self-motivated.

- Have very good written and oral English.

- Have good interpersonal skills.

- Have experience in project management, including the preparation of research proposals.

- Didactic competence and teaching experience.

- Ability and willingness to teach courses in the Biomedical Engineering Bachelor and Master programs.

- Experience with analytical and statistical interpretation of quantitative data as well as Machine Learning would be an additional advantage.

Role:

Biological nanopores are an exciting new class of biosensors, which found practical application is in single-molecule DNA sequencing and single-molecule analysis. The successful candidate will develop, engineer and re-design biological nanopores to identify and characterize regulatory elements as well as detect epigenetic modifications in eukaryotic genomes. Relevant literature includes:

- Wang et al. Single-molecule long-read sequencing reveals the chromatin basis of gene expression. 2019. https://pubmed.ncbi.nlm.nih.gov/31201211/.

- Dhillon et al. Combinatorial analysis of Saccharomyces cerevisiae regulatory elements. 2019. https://www.biorxiv.org/content/10.1101/777763v1.

Initially, part of the work will be dedicated to setting-up the lab (purchasing equipment, developing, and implementing protocols for calibration, performance verification, and operating procedures, establishing a maintenance program, provide training for all operators).

Main responsibilities include:

- Establishing and implementing protocols to sequence eukaryotic genomes and characterize eukaryotic epigenomes using the Oxford NanoporeMinION.

- Designing and implementing protocols for sequencing eukaryotic genomes and characterizing eukaryotic epigenomes using the Oxford NanoporeMinION.

- Developing, optimizing, and improving assays using the Oxford NanoporeMinION.

Independently planning, executing and evaluating laboratory experiments in the field of gene regulation.

- Evaluating, analyzing, and interpreting sequencing data.

- Documenting, representing, and presenting results.

- Preparing scientific publications.

- Teaching.

- Acquisition of research projects and third-party funding.

- Training and further education (participation in conferences, continuing education, etc.).

- Administrative and organizational tasks in teaching and research.

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