美国耶鲁大学医学院药理学系炎症与免疫肿瘤学博士后研究职位招聘

　　Postdoctoral researcher

　　Location: NEW HAVEN, CT

　　Job Number: 7068234

　　Posting Date: Jul 27, 2020

　　Application Deadline: Open Until Filled

　　Job Description

　　Postdoctoral positions are available to study Wnt and GPCR signaling in inflammation and immuno-oncology in the Department of Pharmacology, Yale University School of Medicine, New Haven, CT.

　　Both Wnt proteins and G protein coupled receptors (GPCRs) play important roles in a wide range of biological and pathophysiological processes. We have been using various biochemical, molecular and cell biological, structural biological, genomic, proteomic, large scale RNAi and CRISPR/Kas9 screening, and transgenic and gene targeting approaches to study these pathways. We have made important contributions to characterization of Wnt signaling mechanisms (Mol. Cell 7, 801; Nat Genet. 37, 945; Science 321, 1350; JCB, 200, 419; Nature Comm. 6,8205), a novel tumor immune evasive mechanism (Nat. Med. doi:10.1038/nm.4496), cell migration mechanisms and their roles in inflammatory and vascular diseases (Nature Medicine 22: 1033-42;; Cell Report 14,734; Dve. Cell 27,215; Nature Cell Biology 4, 686; Dev. Cell 21, 1038, Immunity 33, 340, JCI 118, 195, S, Nat. Cell Biol. 7, 399, Cell 114, 215, Science 287, 1046). We continue working along these lines with increased emphasis on tumor immunity and inflammation.

　　Competitive salary and excellent work environment are offered. Self-motivated individuals with an advanced degree in any area of biomedical sciences and specially those who are skilled in immunobiology and bioinformatics are encouraged to apply.

　　The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1,000 employees from 60 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field.

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