美国国家癌症研究所招聘肿瘤生物学、蛋白质化学方向博士后

　　Postdoctoral Fellow - cancer biology, protein chemistry

　　Bethesda, MD, United States

　　Position Description:

　　A postdoctoral position is available in the Molecular and Cell Biology Section (https://ccr.cancer.gov/neuro-oncology-branch/chunzhang-yang) in Neuro-Oncology Branch (NOB), Center for Cancer Research (CCR), National Cancer Institute (NCI) of the National Institutes of Health (NIH).

　　The position is offered to explore the role of oncometabolite and molecular signaling in brain tumors. The research will involve a systematic investigation of the epigenetic changes in oncometabolite-driven cancers. Genetic and biochemical approaches will be employed to characterize the critical epigenetic targets among pathways of DNA repair, metabolism, and therapy resistance. The mechanistic findings will be verified through proof-of-concept investigation with the latest in vitro and in vivo models, as well as patient-derived specimens for validation. Experimental therapeutics are designed based on our preliminary findings, which provide strong justifications for future clinical translation and application.

　　Experience Required:

　　Successful candidates should:

　　1.be highly motivated, able to conduct semi-independent research and function as part of an interdisciplinary team;

　　2. have strong expertise in the fields of cancer biology, molecular biology, biochemistry, epigenetics, and bioinformatics;

　　3. have direct experience with many of the following laboratory techniques: cell culture and transfection, epigenetics, DNA/protein methylation profiling, protein complex profiling, chromatin immunoprecipitation (ChIP), Next-generation sequencing, ChIP-Seq, DNA cloning, and subcloning, and site-directed mutagenesis;

　　4. have expertise in confocal microscopy, flow cytometry and intracranial/subcutaneous mouse xenograft models;

　　5. possess excellent communication skills and be fluent in both spoken and written English.

　　Applicants should have a Ph.D. degree, preferably in biochemistry, molecular biology, genetics, or related field, be near completion of degree  requirements, and have no more than five years of postdoctoral research experience.

　　How To Apply:

　　Please email curriculum vitae, statement of research interests, and three letters of reference to the attention of: Chunzhang Yang, Ph.D., Neuro-Oncology Branch, National Cancer Institute, 37 Convent Drive, Room 1142E, Bethesda, MD 20892 atchunzhang.yang@nih.gov.

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