波士顿儿童医院神经科学、分子生物学方向博士后职位招聘

　　A postdoctoral position is available in the Ozcan Laboratory (www.ozcanlab.com) in the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School.

　　The position is offered to study the role of endoplasmic reticulum (ER) stress signaling in hypothalamic control of metabolic homeostasis, neuron activity and leptin resistance in obesity. The interested candidates can check our recent publications in this area to understand the area of research better:

　　·         Ozcan L, et al. Cell Metabolism. 2009 Jan 7;9(1):35-51. Endoplasmic reticulum stress plays a central role in development of leptin resistance.

　　·         Liu J et al., Cell. 2015 May 21;161(5):999-1011. Treatment of obesity with celastrol.

　　·         Lee J et al., Nature Medicine. 2016 Sep;22(9):1023-32. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice.

　　·         Feng X, et al., Nature Medicine.2019 March 4-Online publication. IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects.

　　The ideal candidate for this position should have a Ph.D., M.D. or M.D./Ph.D. degrees with strong experience in neuroscience and molecular biology evident by peer-reviewed publications in reputable journals. Candidates, who have expertise in electrophysiological recordings of neurons, stereotaxic surgeries and molecular biology with experience in obesity-related metabolic research will be given priority.

　　Interested candidates should forward their research interests, curriculum vitae along with the name and contact information of three referees to Dr. Umut Ozcan; e-mail: umut.ozcan@childrens.harvard.edu

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