招聘简介：

　　博士后研究员-表观遗传机制：昼夜节律时钟代谢功能

　　·希望之城

　　·地点：加利福尼亚州杜阿尔特

　　·工作编号：7058162

　　·发布日期：2019年6月24日

　　·申请截止日期：开放至填写

　　工作描述

　　在霍普市贝克曼研究所糖尿病与代谢研究所的副教授柯马博士的实验室里，可以找到一个博士后研究员职位。MA实验室将最先进的昼夜节律生物学、分子生物学和细胞生物学方法应用于糖尿病和肥胖研究，我们已经建立了一个独特的程序来解释昼夜节律时钟控制代谢组织发育、生长和功能能力的信号机制。

　　我们正在寻找一位对代谢疾病或干细胞研究有强烈热情的积极性的博士后研究员，以发现调节脂肪库和骨骼肌昼夜节律钟功能的新表观遗传机制。最后，我们的目标是为有针对性的治疗干预揭示当前代谢性疾病流行的生理原因。利用生物化学和分子生物学的方法，结合动物生理学在遗传小鼠模型中的应用，MA实验室将探索具体的研究方向：1）外遗传网络介导脂肪组织和骨骼肌中的生物钟营养传感功能；2）骨骼肌发育中干细胞行为的昼夜钟调节。营养、生长和再生；以及3）昼夜节律调节器在癌症发展和代谢中的新作用。

　　英文原文：

　　Postdoctoral Fellow - Epigenetic Mechanisms: Circadian Clock Metabolic Function

　　·         City of Hope

　　·         Location: Duarte, CA

　　·         Job Number: 7058162

　　·         Posting Date: Jun 24, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　A Postdoctoral Fellow position is available in the laboratory of Dr. Ke Ma, Associate Professor, at the Diabetes and Metabolism Research Institute within Beckman Research Institute of City of Hope. The Ma lab applies state-of-the-art circadian biology, molecular and cellular biology approaches to diabetes and obesity research, and we have established a unique program in deciphering the signaling mechanisms underlying circadian clock control in metabolic tissue development, growth and functional capacity.

　　We are looking for a highly motivated postdoctoral fellow with strong enthusiasm for metabolic disease or stem cell research to discover novel epigenetic mechanisms mediating circadian clock functions in adipose depots and skeletal muscle. Ultimately, our goal is to unravel circadian etiologies underlying the current epidemics of metabolic diseases for targeted therapeutic interventions. Utilizing biochemical and molecular biology approaches combined with animal physiology in genetic mouse models, the specific research directions in Ma Lab will explore, 1) epigenetic networks mediating clock nutrient-sensing function in adipose tissue and skeletal muscle; 2) circadian clock regulation of stem cell behavior in skeletal muscle development, growth, and regeneration; and 3) novel roles of circadian regulators in cancer development and metabolism.

　　The candidate should be self-motivated, with a proven track record of productivity and strong interest in metabolic disease, epigenetics or stem cell research.

　　For a list of lab publications, please click here.

　　Basic education, experience and skills required for consideration:

　　PhD in Molecular, Cellular or Developmental Biology;

　　Proficiency with biochemical techniques, molecular biology skills and cell culture systems;

　　Highly motivated with strong interest in metabolic disease research;

　　Strong work ethic and ability to work effectively in a team.

　　Preferred education experience and skills:

　　Experience with in vivo animal model research;

　　Experience in biochemistry and gene regulation;

　　Experience with epigenetics research and genomic bioinformatics analysis;

　　Technical skills in metabolic, epigenetics, and stem cell research.

　　Additional Information:

　　For more information about Dr. Ma’s lab, please click here;

　　To apply, please provide your CV, a brief research statement and a list of three references.

　　City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.