招聘简介：

　　博士后研究员-脂肪组织重塑和代谢紊乱

　　·希望之城

　　·地点：加利福尼亚州杜阿尔特

　　·工作编号：7058164

　　·发布日期：2019年6月24日

　　·申请截止日期：开放至填写

　　工作描述

　　希望之城贝克曼研究所正在分子和细胞内分泌学系的王琼博士（安娜贝尔）的实验室里寻找一位有才华的博士后。

　　王实验室利用先进的组织特异性、诱导性敲除和谱系追踪小鼠模型，研究脂肪组织在胰岛素抵抗、肥胖和癌症等生理和病理条件下的区域特异性重塑。王博士之前已经建立了脂肪追逐者小鼠模型，并在脂肪组织发育和重塑过程中跟踪脂肪生成（王QA等。《自然医学》，2013年）。王博士的另一项研究揭示了体内脂肪生成不同阶段所需的转录信号的惊人多样性（王QA等人《自然细胞生物学》，2015年）。王实验室目前正在研究两个项目：1）棕色脂肪组织异质性，以及这种异质性如何重塑棕色脂肪细胞在健康和疾病中的产热能力。2）生育期间乳腺中的白色脂肪组织重塑，以及这种重塑如何导致全身代谢紊乱和乳腺癌（王卡，等。细胞代谢，2018年）。

　　我们正在寻找一位积极性很高的博士后研究员，他有兴趣研究导致肥胖、糖尿病和癌症的细胞和代谢机制。这个职位需要在分子生物学和啮齿动物模型方面有丰富的经验。

　　英文原文：

　　Postdoctoral Fellow - Adipose Tissue Remodeling and Metabolic Disorders

　　·         City of Hope

　　·         Location: Duarte, CA

　　·         Job Number: 7058164

　　·         Posting Date: Jun 24, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow in the laboratory of Dr. Qiong (Annabel) Wang, in the Department of Molecular and Cellular Endocrinology.

　　The Wang laboratory utilizes the cutting-edge tissue specific, inducible knockout and lineage tracing mouse models to study the region-specific remodeling of adipose tissue, both in physiological and pathological conditions, such as insulin resistance, obesity and cancer. Dr. Wang has previously generated the AdipoChaser mice model and tracked adipogenesis during adipose tissue development and remodeling (Wang QA, et al. Nature Medicine, 2013). Dr. Wang’s another research revealed the surprising diversity of transcriptional signals required at different stages of adipogenesis in vivo (Wang QA, et al. Nature Cell Biology, 2015). The Wang lab is currently working on two projects: 1) Brown adipose tissue heterogeneity, and how this heterogeneity remodels the thermogenic capacity of brown adipocytes in health and disease. 2) White adipose tissue remodeling in the mammary gland during reproduction, and how this remodeling contributes to whole body metabolic disorders and breast cancer (Wang QA, et al. Cell Metabolism, 2018).

　　We are seeking a highly motivated postdoctoral fellow interested in studying the cellular and metabolic mechanisms leading to obesity, diabetes and cancer. The position requires extensive experience in molecular biology and rodent models.

　　Basic education, experience and skills required for consideration:

　　A Ph.D. degree in Molecular, Cellular, or Chemical Biology, or in life or biomedical sciences, or a related discipline is required.

　　Extensive experience with basic molecular biology skills.

　　Extensive experience in animal models.

　　Experience with immunofluorescence staining and flow cytometry.

　　Excellent written and verbal communication skills.

　　Good problem solving skills, ability to conduct independent research, ability to work effectively in a team.

　　Additional Information:

　　To apply, please include your CV and a list of three references.

　　For more information about Dr. Wang’s research, please click here.

　　City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.