招聘简介：

　　·迈阿密大学

　　·地点：佛罗里达州迈阿密

　　·工作编号：7057026

　　·入账日期：2019年4月17日

　　·申请截止日期：开放至填写

　　职位描述

　　迈阿密大学米勒医学院西尔维斯特综合癌症中心的莫里博士实验室有两个博士后研究员职位。Morey实验室专注于表观遗传学机制，控制癌症的发生和发展，以及干细胞分化。

　　我们实验室的前期工作表明，多梳组（PCG）复合物的结构有助于调节干细胞命运的决定（Morey等人细胞干细胞，2012；Morey等人Cell Reports，2013年；Morey等人细胞干细胞，2015年）。最近，我们发现PCG复合物被招募到多种癌症的活性增强剂中，突出了PCG复合物在调节癌症中的致癌转录程序方面的功能探索不足（Chan等人Nature Comm，2018；Chan和Morey，生物化学趋势，出版）。

　　英文原文：

　　·         University of Miami

　　·         Location: Miami, FL

　　·         Job Number: 7057026

　　·         Posting Date: Apr 17, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　Two postdoctoral fellow positions are available in Dr. Morey’s lab at Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine. The Morey lab focuses on the epigenetic mechanisms that control cancer initiation and progression, and stem cell differentiation.

　　Previous work in our lab have shown that the architecture of Polycomb-group (PcG) complexes is instrumental in regulating stem cell fate decisions (Morey et al. Cell Stem Cell, 2012; Morey et al. Cell Reports, 2013; Morey et al. Cell Stem Cell, 2015). Recently, we have discovered that PcG complexes are recruited to active enhancers in multiple cancers, highlighting an under-explored function of PcG complexes in regulating oncogenic transcriptional programs in cancer (Chan et al. Nature Comm, 2018; Chan and Morey, Trends in Biochemical Sciences, in press).

　　Two Postdoctoral fellow positions:

　　Our research program aims to characterize the PcG-mediated mechanisms in multiple cancer types, including breast cancer (position 1), and in human pluripotent stem cell differentiation (position 2). The projects will employ genetic, biochemical and genomic approaches including 3D chromatin architecture assays (HiC and HiChIP) and CRISPR/Cas9 screens, as well as standard genome-wide assays (ChIP- RNA- ATAC-seq). Experiments will be performed using both cell culture (cancer cells and human embryonic stem cells) and in vivo models (xenografts and PDX models).

　　Successful candidates will have earned a Ph.D. in genetics, molecular biology, cellular biology, or related fields and demonstrated the ability to complete research projects independently. Expertise in epigenetics in any model system will greatly strengthen the application. Experience with computational analysis of genomic data is a plus but is not required.

　　For additional information please visit our webpages:

　　www.moreylab.com

　　www. sylvester.org

　　Interested candidates are invited to contact Dr. Lluis Morey (lmorey@med.miami.edu ) with CV and names of two references.