招聘简介：
在许多合作项目中开放博士后职位以研究ApoA-I结合蛋白的结构功能和生物学（AIBP;请参考Nature 2013,498：118-22; Cell Rep 2018,23（9）：2667-77; JCI Insight 2018,3（16）pii：120519; J Lipid Res。2018,59（5）：854-863），该蛋白质选择性调节发炎和胆固醇过多细胞中的脂筏。加利福尼亚大学圣地亚哥分校Yury Miller实验室的研究是胆固醇代谢/脂筏，血管和神经炎症，神经性疼痛和神经变性的交叉点。一个项目是与Robert Rissman的实验室合作，使用细胞和小鼠模型研究AIBP在神经炎症和神经变性中的保护作用。另一个项目与Irina Kufareva实验室合作，重点关注AIBP-TLR4和AIBP-载脂蛋白相互作用的结构决定因素。成功的候选人将是最近的博士研究生（0-1岁），具有强大的出版记录和在分子生物学，神经元/神经胶质细胞生物学，高分辨率成像和/或神经变性小鼠模型方面的专业知识。这些研究员将成为一个充满活力的研究团体的一部分，结合参与脂质异常，动脉粥样硬化，神经炎症，神经性疼痛，阿尔茨海默氏症和其他神经退行性疾病的机制的见解，重点关注科学发现转化为临床。请将一封求职信以及简历和3名裁判的姓名发送给Yury Miller，yumiller @ usdd.edu。
英文原文：
Open postdoctoral positions in a number of collaborative projects to study structure-function and biology of ApoA-I Binding Protein (AIBP; please refer to Nature 2013, 498:118-22; Cell Rep 2018, 23(9):2667-77; JCI Insight 2018, 3(16) pii: 120519; J Lipid Res. 2018, 59(5):854-863), the protein that selectively regulates lipid rafts in inflamed and cholesterol-overloaded cells. The research in Yury Miller’s laboratory at the University of California, San Diego is at the intersection of cholesterol metabolism/lipid rafts, vascular and neuro inflammation, neuropathic pain and neurodegeneration. One project is a collaboration with Robert Rissman’s lab to study protective role of AIBP in neuroinflammation and neurodegeneration, using cellular and mouse models. Another project, in collaboration with Irina Kufareva’s lab, focuses on structural determinants of AIBP-TLR4 and AIBP-apolipoprotein interactions. The successful candidate will be a recent PhD graduate (0-1 years) with a strong publication record and demonstrated expertise in molecular biology, neuronal/glial cell biology, high-resolution imaging and/or mouse models of neurodegeneration. The fellows will be part of a vibrant research community combining insights from mechanisms involved in the development of lipid abnormalities, atherosclerosis, neuroinflammation, neuropathic pain, Alzheimer’s and other neurodegenerative diseases, with a strong focus on translation of scientific discoveries into clinic. Please send a cover letter together with the CV and names of 3 referees to Yury Miller, yumiller@ucsd.edu .
