招聘信息：

　　隶属于匹兹堡大学医学院

　　博士后职位可用于在斯图尔特 - 奥恩斯坦实验室进行一项关于DNA损伤信号传导的NCI资助项目。在最近在匹兹堡大学计算和系统生物学系建立的斯图尔特-奥恩斯坦实验室，我们寻求了解DNA损伤信号如何在我们体内的组织中进行调整并在癌症中进行修饰，以开发改进的和更精确的靶向治疗。我们的实验室位于希尔曼癌症中心，并且位于匹兹堡大学的一个非常强大的基因组稳定组中，该组在全国NIH资助中排名第五。

　　Stewart-Ornstein实验室使用湿式和干式实验室方法，并且两者都欢迎专业知识，尽管理想的候选人会对研究的两个方面都感兴趣。我们使用活细胞成像，单细胞方法，遗传筛选（cas9ko，cas9i），基因组工具（RNA的NGS分析，ChIP，染色质结构）和数学模型来研究DNA损伤信号的变异并理解这种信号传导的可能性被操纵以改善癌症治疗。项目最初将关注非遗传细胞状态如何改变DNA损伤反应并促进化疗和放射治疗后的持久性。 DNA损伤信号传导与致癌和免疫信号传导途径之间的联系也是感兴趣的领域。

　　资格要求：

　　-PhD分子，系统或计算生物学或类似的。

　　- 独立和协作的工作，强大的写作和演讲技巧

　　- 重要的出版记录

　　有意者请将您的简历和三个参考名称转发给Jacob Stewart-Ornstein博士（JAS632@pitt.edu）。

　　匹兹堡大学提供全面的薪资计划，并在无烟和无毒的工作场所提供卓越的福利。匹兹堡大学医学院是一个肯定行动/平等机会雇主，并鼓励代表性不足的团体提出申请。 EEO / AA / M / F兽医/残疾人士。

　　联系人：

　　Jacob Stewart-Ornstein，博士

　　助理教授：

　　计算与系统生物学系

　　美国匹兹堡和希尔曼癌症中心

　　（e）jas632@pitt.edu

　　（p）4126233245

　　（w）www.Stewart-Ornstein-Lab.com

　　Affiliated with University of Pittsburgh School of Medicine

　　Postdoctoral positions are available to pursue an NCI funded project on DNA damage signaling in the Stewart-Ornstein Laboratory. In the recently established Stewart-Ornstein Laboratory in Department of Computational and Systems Biology at the University of Pittsburgh we seek to understand how DNA damage signaling is tuned across tissues in our body and modified in cancers for the purposes of developing improved and more precisely targeted therapies. Our lab is based at the Hillman Cancer Center and embedded within a very strong genome stability group at the University of Pittsburgh, which ranks fifth in NIH funding nationally.

　　The Stewart-Ornstein laboratory uses both wet and dry lab approaches and expertise is welcomed in either, though the ideal candidate would have interest in both aspects of research. We use live cell imaging, single cell approaches, genetic screens (cas9ko, cas9i), genomic tools (NGS assays of RNA, ChIP, Chromatin structure), and mathematical models to study the variation in DNA damage signaling and to understand how this signaling might be manipulated to improve cancer therapy. Projects will initially focus on how non-genetic cellular states alter the DNA damage response and promote persistence after chemotherapy and radiation treatment. Linkages between DNA damage signaling and oncogenic and immune signaling pathways are also areas of interest.

　　Qualification Requirements

　　-PhD in molecular, systems, or computational biology or similar.

　　-Capable of independent and collaborative work, strong writing and presentation skills

　　-Significant publication record

　　Interested candidates please forward your curriculum vitae and names of three references to Dr. Jacob Stewart-Ornstein (JAS632@pitt.edu).

　　The University of Pittsburgh offers a comprehensive salary program and excellent benefits in a smoke and drug free workplace. The University of Pittsburgh School of Medicine is an Affirmative Action/Equal Opportunity Employer and encourages applications from under-represented groups. EEO / AA/ M /F Vets / Disabled.

　　Contact

　　Jacob Stewart-Ornstein, PhD

　　Assistant Professor

　　Dept. Computational and Systems Biology

　　U. Pittsburgh & Hillman Cancer Center

　　(e) jas632@pitt.edu

　　(p) 4126233245

　　(w) www.Stewart-Ornstein-Lab.com