招聘信息：
我们正在寻找一位敏锐而有才华的博士后研究员加入我们在病童医院的转化欧洲肿瘤学实验室。病童医院的Ramaswamy实验室开展了儿科脑肿瘤转化基因组学研究，其首要目标是为患有高危复发性肿瘤的儿童发现新的和新的疗法。我们使用主要人类数据集与无偏见的化学和遗传筛选相结合，为新的治疗途径提供信息，然后在稳健的动物模型中验证这些方法。我们试图了解高风险儿科脑肿瘤对放疗和化疗的治疗耐药性，对髓母细胞瘤和室管膜瘤特别感兴趣。我们也非常关注为预后和治疗反应开发新的生物标志物，并将这些与新的和新的疗法相结合。
我们的实验室位于亚瑟和索尼亚拉巴特脑瘤研究中心，该研究中心是世界上最大和最具生产力的儿科脑肿瘤研究中心之一。我们有11名主要研究人员和120多名受训人员，研发空间为120000平方英尺，开放式概念设置侧重于脑瘤研究的各个方面。在过去20年中，我们的小组一直处于儿科脑肿瘤主要发现的最前沿，并且一直是所有类型小儿脑肿瘤基因组学的领导者。此外，我们是Sickkids研究所的发育和干细胞生物学计划的一部分，为癌症和干细胞生物学提供了非常丰富的专家环境。儿童医院位于多伦多大学，玛格丽特公主癌症中心和安大略癌症研究所的街对面，除了我在医学生物物理系的所属部门之外，我们还与世界一流的科学家进行了广泛的合作。我们的团队通过国家授权机构提供充足的资金，并将提供丰富，有趣和培育的环境。
候选人必须已经（或预计很快就会获得）博士学位。并且在分子生物学，癌症生物学或相关学科方面拥有丰富的经验，并且理想地具有人类基因组学和/或功能基因组学的背景。这个职位将高度重视以下技能：
- 癌症干细胞培养方法和流式细胞术
- 动物模型，特别是正交异种移植物
- 理想情况下是R和/或Python的工作知识
- 使用遗传学和组学数据的经验
- 癌症生物学知识是一个重要的优点
- 一份或多份同行评审科学出版物的第一（或共同首位）作者
- 优秀的英语口头和书面沟通技巧
- 能够独立和团队合作
有兴趣的候选人应发送他们的简历，先前研究经验的总结，未来的研究兴趣和职业目标，以及vijayramaswamy79 @gmail.com的Vijay Ramaswamy博士的三个参考清单。
英文原文：
We are seeking a keen and talented postdoctoral fellow to join our translational euro-oncology laboratory at the Hospital for Sick Children. The Ramaswamy Lab at the Hospital for Sick Children performs studies of translational genomics of paediatric brain tumours with an overarching goal of discovering new and novel therapies for children with high-risk recurrent tumours. We use primary human datasets coupled with unbiased chemical and genetic screening to inform new treatment avenues, and then validate these approaches in robust animal models. We seek to understand treatment resistance to both radiation and chemotherapy in high risk paediatric brain tumours, with a specific interest in medulloblastoma and ependymoma. We also have a keen interest in developing new biomarkers for both prognosis and response to therapy and to combine these with new and novel therapies.
Our laboratory is located within the Arthur and Sonia Labatt Brain Tumour Research Centre which is one of the largest and productive paediatric brain tumour groups in the world. We have 11 principal investigators and over 120 trainees with 120000 sq ft. of research space, in an open concept setting focused on all aspects of brain tumour research. Our group have been at the forefront of major discoveries in paediatric brain tumours over the past 20 years, and have been a leader in the genomics of all types of paediatric brain tumours. Furthermore, we are part of the Programme in Developmental and Stem Cell Biology within the Sickkids Research Institute providing a very rich environment of experts in cancer and stem cell biology. The Hospital for Sick Children is located across the street from the University of Toronto, Princess Margaret Cancer Centre and Ontario Institute for Cancer Research where we have extensive collaborations in addition to my affiliation in the Department of Medical Biophysics provides access to world class scientists. Our group is well funded through national granting agencies, and will provide a rich, fun and nurturing environment.
Candidate must have received (or expect to receive soon) a Ph.D. and have extensive experience in molecular biology, cancer biology or related discipline and ideally have a background in human genomics and/or functional genomics. The following skills will be highly valued for this position:
- Cancer stem cell culture methods and flow cytometry
- Animal modelling, particularly orthotropic xenografts
- Ideally a working knowledge in R and/or Python
- Experience working with genetics and omics data
- Knowledge of cancer biology is a major plus
- First (or co-first) author of one or more peer-reviewed scientific publications
- Excellent English verbal and written communication skills
- Able to work both independently and in teams
Interested candidates should send their CV, summary of prior research experience, future research interests and career goals and a list of three references to Dr. Vijay Ramaswamy at vijayramaswamy79@gmail.com.
