Postdoc Position in Characterization of Non-Alcoholic SteatoHepatitis (NASH) Using Clinical Proteomics and PTMomics at Department of Biochemistry and Molecular Biology

　　University of Southern Denmark (SDU)

　　Main objectives of the postdoc project (three years)

　　o    To identify circulating proteins (or specific PTMs) that correlate with key features of liver histopathology, primarily fibrosis, inflammation and/or hepatocyte ballooning, in the context of NASH in rodent and/or hepatocellular or liver tissue ex vivo models.

　　o    To explore the biological mechanism/s of action of key factor/s in the pathogenesis or resolution of NASH in in vitro and/or in vivo models.

　　o    To validate these factor/s in human clinical cohorts to determine their predictive validity in identifying NASH patients and/or with NASH resolution in clinical trial cohorts or subsets of human subjects.

　　o    Toperform methodological developments within the clinical proteomics field and in PTMomics characterization of cellular signalling pathways.

　　Qualifications

　　A successful candidate would have a PhD degree in biochemistry, cell biology, molecular biology, proteomics or a related field and is highly motivated and innovative. A candidate with significant experience in functional proteomics, post-translational modification analysis, LC-based mass spectrometry and bioinformatics is preferable. However, knowledge in diabetes and NASH diseases is a significant merit. Excellent communication and writing skills and an ability to interact socially and scientifically with other laboratory members and collaborators are essential. Previous postdoc experience and a strong publication record are also strong merits.

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